PUBLICATIONS
Hu, Y., Sun, H.-X., Sakurai, M., Luo, Z., Jones, A. E., Cheng, T., Huang, J., Liu, L., Zheng, C., Li, J., Lu, Y., Ravaux, B., He, B., Ding, Y., Liu, T., Wu, Y., Chen, Z. J., Abrams, J. M., Chen, E. H.,…Wu, J. (2025). RNA innate immunity constitutes a barrier for interspecies chimerism. Cell. doi.org/10.1016/j.cell.2025.10.039
Liu, L., & Wu, J. (2025). Stem cell-based models of early human development. Development, 152(8). doi.org/10.1242/dev.204543
Ballard, E., Sakurai, M., Yu, L., Liu, L., Oura, S., Huang, J., & Wu, J. (2024). Incompatibility in cell adhesion constitutes a barrier to interspecies chimerism. Cell Stem Cell, 31(10), 1419–1426 e1417. doi.org/10.1016/j.stem.2024.07.010
Wei, Y., Zhang, E., Yu, L., Ci, B., Sakurai, M., Guo, L., Zhang, X., Lin, S., Takii, S., Liu, L., Liu, J., Schmitz, D. A., Su, T., Zhang, J., Shen, Q., Ding, Y., Zhan, L., Sun, H. X., Zheng, C.,…Wu, J. (2023). Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture. Cell, 186(26), 5859–5875 e5824. doi.org/10.1016/j.cell.2023.11.008
Liu L, Oura S, Markham Z, Hamilton JN, Skory RM, Li L, Sakurai M, Wang L, Pinzon-Arteaga CA, Plachta N, Hon GC, Wu J. Modeling post-implantation stages of human development into early organogenesis with stem-cell-derived peri-gastruloids. Cell. 2023 Jul 19: S0092-8674(23)00794-8. doi: 10.1016/j.cell.2023.07.018 **Cover article**
Yu, L., Logsdon, D., Pinzon-Arteaga, C.A., Duan, J., Ezashi, T., Wei, Y., Ribeiro Orsi, A.E., Oura, S., Liu, L., Wang, L., et al. Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk. Cell Stem Cell. 2023 Sep 7;30(9):1246-1261.e9. doi: 10.1016/j.stem.2023.08.002
Gong Y, Bai B, Sun N, Ci B, Shao H, Zhang T, Yao H, Zhang Y, Niu Y, Liu L, Zhao H, Wu H, Zhang L, Wang T, Li S, Wei Y, Yu Y, Ribeiro Orsi AE, Liu B, Ji W, Wu J, Chen Y, Tan T. Ex utero monkey embryogenesis from blastocyst to early organogenesis. Cell. 2023 May 11;186(10):2092-2110.e23. doi: 10.1016/j.cell.2023.04.020
Pinzón-Arteaga CA, Wang Y, Wei Y, Ribeiro Orsi AE, Li L, Scatolin G, Liu L, Sakurai M, Ye J, Hao Ming, Yu L, Li B, Jiang Z, Wu J. Bovine blastocyst-like structures derived from stem cell cultures. Cell Stem Cell 2023 May 4;30(5):611-616.e7. doi: 10.1016/j.stem.2023.04.003
Zhai J*, Guo J*, Wan H*, Qi L*, Liu L*, Xiao Z, Yan L, Schmitz DA, Xu Y, Yu D, Wu X, Zhao W, Yu K, Jiang X, Guo F, Wu J, Wang H. Primate gastrulation and early organogenesis at single-cell resolution. Nature. 2022 Dec;612(7941):732-738. doi: 10.1038/s41586-022-05526-y *: Equal contribution
Liu L, Nemashkalo A, Rezende L, Jung JY, Chhabra S, Guerra MC, Heemskerk I, Warmflash A. Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids. Nat Commun. 2022 Jan 25;13(1):497. doi: 10.1038/s41467-022-28149-3 **Featured article**
Liu L, Warmflash A. Self-organized signaling in stem cell models of embryos. Stem Cell Reports 2021 May 11;16(5):1065-1077. doi: 10.1016/j.stemcr.2021.03.020
Lee S, Ding N, Sun Y, Yuan T, Li J, Yuan Q, Liu L, Yang J, Wang Q, Kolomeisky AB, Hilton IB, Zuo E, Gao X. Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects. Sci Adv. 2020 Jul;6(29):eaba1773. doi: 10.1126/sciadv.aba1773
Chhabra S, Liu L, Goh R, Kong X, Warmflash A. Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. PLoS Biol. 2019 Oct;17(10):e3000498. doi: 10.1371/journal.pbio.3000498
Heemskerk I, Burt K, Miller M, Chhabra S, Guerra MC, Liu L, Warmflash A. Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells. Elife. 2019 Mar 4;8. doi: 10.7554/eLife.40526
Liu L, Huang W, Huang JD. Synthetic circuits that process multiple light and chemical signal inputs. BMC Syst Biol. 2017 Jan 19;11(1):5. doi: 10.1186/s12918-016-0384-y **Featured article**
Tang MM, Zhu QE, Fan WZ, Zhang SL, Li DZ, Liu LZ, Chen M, Zhang M, Zhou J, Wei CJ. Intra-arterial targeted islet-specific expression of Sirt1 protects β cells from streptozotocin-induced apoptosis in mice. Mol Ther. 2011 Jan;19(1):60-6. doi: 10.1038/mt.2010.187
Liu C, Fu X, Liu L, Ren X, Chau CK, Li S, Xiang L, Zeng H, Chen G, Tang LH, Lenz P, Cui X, Huang W, Hwa T, Huang JD. Sequential establishment of stripe patterns in an expanding cell population. Science. 2011 Oct 14;334(6053):238-41. doi: 10.1126/science.1209042